What Happens in the Short-Term?
THC gets movin’ quickly. Within seconds, the drug hits the brain and goes to town on the brain’s cells, called neurons. To understand how this works, let’s pause for a brief biology lesson. Neurons are long, dangly cells that don’t actually touch one another. The gap between brain cells is called a synapse, and the brain uses chemicals calledneurotransmitters to pass messages across these gaps — think of these chemicals as an operator on a phone call. You’ve probably heard of a few neurotransmitters, like serotonin, epinephrine, and dopamine. While most neurotransmitters are made in the glands, some man-made drugs (both legal and illegal) can mimic the same effects as natural neurotransmitters. Natural or not so much, a neurotransmitter binds to a neuron, which signals the body to do (or not do) something. When a neurotransmitter fits into the correct receptor—like a key in a lock—it chemically turns that neuron off or on.
This is where our friend THC comes in. The active chemical in marijuana mimics a natural neurotransmitter called anandamide. Anandamide is often referred to as the “bliss molecule” because of its role in boosting memory and learning, dulling pain, and stimulating the appetite . Anandamide normally buddies up with dopamine, and together these neurotransmitters turn on and turn off different chemical pathways as needed.
THC may mimic anandamide, but they don't produce the exact same effects. After a person takes a hit of Mary Jane, THC binds to cannabinoid CB1 and CB2 receptors, which are located in several parts of the brain (namely, the hippocampus, cerebral cortex, cerebellum, and basal ganglia) . These brain areas are responsible for short-term memory, coordination, learning, problem solving, and unconscious muscle movements. When THC gets its groove on in the cannabinoid receptors, it gets in the way of natural neurotransmitters (like anandamide) that need to bind to those sites to make all of the functions listed above work properly.
When THC prevents anadamide from doing its job, the delicate balance between anadamide and dopamine is thrown off. The result: We’re suddenly euphoric, off-balance, ravenous, seemingly impervious to pain, and unable to retain information. Think about theclassic stoner clichés for a minute…yep, all the signs and symptoms are there.
What Happens in the Long-Term?
How long THC affects the brain and stays in the body depends onmany factors, including the potency of the marijuana, the smoker’s experience with the drug, how the drug is ingested (via joint, bowl, bong, vaporizer, etc), and if it’s used in conjunction with other drugs or alcohol . Immediate effects of THC kick in after a few seconds and last for an hour or two, but the chemicals can stay in the body for much longer. THC is fat-soluble, so even though it doesn’t continue to affect the brain, it can hang out in body tissues for several weeks or, in the case of habitual smokers, even months .
So are those wild ‘n’ crazy nights going to ruin your brain forever?Some studies have shown that frequent adolescent marijuana use—especially when use begins at a younger age—can reduce IQ by middle age. Further research argues that smoking like a chimney causes overuse of the CB1 receptors, which can lead to a sloth-like brain. But more recently, a boatload of researchers have proven that puffing the magic dragon won’t actually zap your brain cells in the long-term. .
But Then I Got High: The Takeaway
If you stuck through the chemistry lessons until this part, you’re probably expecting a thumbs-up or thumbs-down judgment. But, as with many biological processes, the overall effect of marijuana on brain chemistry isn’t crystal clear. For the most part, current research is disproving earlier studies that claimed that marijuana damaged the body long-term, but so far nothing’s really set in stone. Feel free to take this information on the brain’s reaction to marijuana and smoke it (or not).
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